Epstein Barr Virus - searching for a metabolic Achilles' heel
In-person only
EBV is a B cell tropic, oncogenic gamma-herpes virus that infects more than 90% of the adult population worldwide. In immunosuppressed individuals, EBV may cause a wide spectrum of pathologies, ranging from lymphoproliferation to frank lymphoma.
EBV-driven B cell expansion is a metabolically demanding process. Targeting metabolic vulnerabilities of B cells en route to virus-driven transformation may thus offer therapeutic opportunities.
In my seminar, I will present emerging data on EBV-driven metabolic changes required for latent infection of B cells. Molecular metabolic aspects, preclinical models and clinical data will be discussed.
Date:
13 May 2024, 12:00 (Monday, 4th week, Trinity 2024)
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Prof Christoph Hess (University of Cambridge)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Dr Alex Clarke (Univeristy of Oxford - The Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
