Tracking Jak-STAT signalling in inflammatory arthritis
This seminar will be held using Zoom. Please join here: https://zoom.us/meeting/register/tJwrdeuvpz0uHNOzE5-OMiSw1_1BfZ3oFReZ
Immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA) are highly context dependent. Rheumatoid arthritis patients often display very different patterns of local synovial pathology– termed fibroblast-rich, myeloid-rich and lymphoid-rich synovitis. My overarching goal is to identify the decision-making processes affecting the clinical presentation of these synovial pathotypes. Combining functional genomic approaches and histological studies in mice and humans I will discuss how cells within the inflamed synovium sense and interpret cytokine cues linked with these pathotypes. With a primary focus on cytokines that signal through the latent transcription factors STAT1 and STAT3, I will provide new insights into the potential role of protein tyrosine phosphatases as biological rheostats of Jak STAT signalling within the inflamed joint.
Date: 21 September 2020, 12:00 (Monday, -2nd week, Michaelmas 2020)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please join here: https://zoom.us/meeting/register/tJwrdeuvpz0uHNOzE5-OMiSw1_1BfZ3oFReZ
Speaker: Prof Simon Jones (Cardiff University)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://zoom.us/meeting/register/tJwrdeuvpz0uHNOzE5-OMiSw1_1BfZ3oFReZ
Audience: Public
Editor: Jennifer Pope