The Human Cell Atlas & mapping the intestines one cell at a time
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJwofuGspz4jHtwqf_P7UxBNUoZJdpg8Jpyn
The cellular landscape of the human gastrointestinal tract is dynamic throughout life, changing in response to changing functional requirements and environmental exposures. While the human intestines has been explored in depth, we present a comprehensive single-cell analysis across gut regions, and throughout development, adulthood for the first time. Using single-cell RNAseq and VDJ analysis, we survey all cell lineages in the healthy developing, paediatric and adult human gut, including 347,980 cells from up to 10 distinct anatomical sites. We identify BEST4+ enterocytes throughout the gut and implicate Tuft cells in IgG sensing. We define novel cell populations in the developing enteric nervous system and show patterned expression of irritable bowel syndrome and Hirschsprung’s disease. In addition, we identify key cell players and communication networks initiating lymphoid structure formation in early human development. We show that lymphoid organogenesis programs are adopted in inflammatory bowel disease to recruit and retain immune cells at the site of inflammation.
Date: 14 June 2021, 12:00 (Monday, 8th week, Trinity 2021)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJwofuGspz4jHtwqf_P7UxBNUoZJdpg8Jpyn
Speaker: Dr Sarah Teichmann (Wellcome Sanger Institute)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Prof Chris Buckley (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://zoom.us/meeting/register/tJwofuGspz4jHtwqf_P7UxBNUoZJdpg8Jpyn
Audience: Public
Editor: Jennifer Pope