Regulation of protein synthesis and proteostasis by the Integrated Stress Response’
The regulated phosphorylation and de-phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2) potently regulates global and gene-specific mRNA translation and thereby broadly affects proteostasis in diverse physiological and pathological settings. Phosphorylated eIF2 is a convergence point for several stress response pathways and its downstream effector processes are known as the integrated stress response (or ISR). In this talk I will review recent advances in our understanding of the ISR and its role in proteostasis.
Date: 23 November 2023, 16:00 (Thursday, 7th week, Michaelmas 2023)
Venue: Sherrington Building
Speaker: Professor David Ron (University of Cambridge)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Prof David Paterson (University of Oxford)
Organiser contact email address: communications@dpag.ox.ac.uk
Host: Prof David Paterson (University of Oxford)
Part of: John Scott Haldane Prize Lecture
Booking required?: Not required
Audience: Members of the University only
Editor: Peter Belk