This seminar is a fusion of clinical focus on mood disorder, bipolar specifically but with reference to other severe mental illness – schizophrenia and major depression, by an update of a case along with related clinical trial outcomes. The RCT arose from the case but the theoretical framework included findings from epidemiological studies on the aetiology of schizophrenia and biological research on photoperiod, melatonin and development. Sleep is a need around which pivot symptoms can emerge in the above conditions when sub-optimal and circadian rhythms are becoming more fully understood. Their applicability to mood disorder and relapse are incorporated in the planned exploratory analyses now being carried out on sleep data from the RCT as well as in a further study utilising serum from bipolar patients who participated in the RCT of melatonin in acute mania (MIAMI-UK). It is hoped the presentation will stimulate discussion and questions relevant to the planning in progress for a larger RCT in bipolar, which will include measurement of sleep and phase.

zoom.us/j/97234106780?pwd=OEtUaDJsS3UrUklhZHRyOFVDK3p0Zz09

Meeting ID: 972 3410 6780
Passcode: 004054