Seminar by Prof Awen Gallimore 'Modifying the tumour microenvironment to promote tumour immunity'
This seminar will be held in the Kennedy Institute Lecture Theatre with the option to join via Zoom https://medsci.zoom.us/meeting/register/tJMrcOGprDIvGtU7RAeuLTRIE7Xjsg2Mui5F
We have evidence that the anti-tumour T cell response can, under certain circumstances, drive structural alterations to the tumour microenvironment (TME) which serve to amplify the immune response leading to tumour destruction. Data will be presented which indicates that changes to the TME are widespread and are characterized by the development of specialised blood vessels named high endothelial venules (HEV), re-organization of lymphatic vessels and loss of extracellular matrix (ECM). How these individual features interact and synergise to create conditions favouring immune-mediated cancer destruction will be discussed along with the pivotal role played by antigen-specific T cells.
Date:
12 September 2022, 12:00 (Monday, 21st week, Trinity 2022)
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
We are returning to in person seminars in the Kennedy Institute Lecture Theatre with the option to join via Zoom https://medsci.zoom.us/meeting/register/tJMrcOGprDIvGtU7RAeuLTRIE7Xjsg2Mui5F
Speaker:
Prof Awen Gallimore (Cardiff University)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
ellen.mobbs@kennedy.ox.ac.uk
Host:
Professor Fiona Powrie (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Elizabeth Thompson,
Ellen Mobbs
