Seminar by Prof Steve Ley "CARD14 signalling in psoriasis"
The laboratory of Anne Bowcock showed in 2012 that rare inherited and de novo mutations in Card14 promote development of psoriasis. My group demonstrated in 2016 that psoriasis-associated Card14 mutations disrupt an intramolecular interaction in CARD14 and induce constitutive formation of a CARD14/BCL10/MALT1 complex, that triggers activation of NF-κB in keratinocytes. I will present our ongoing experiments to investigate how dysregulated CARD14 induces psoriasis. These have involved analyses of a new knock-in mouse strain in which the conditional expression of a psoriasis-associated CARD14 variant induces psoriasiform dermatitis and biochemical analyses of CARD14 signalling pathways in keratinocytes. These studies have significantly increased our understanding of the role of CARD14 in psoriasis aetiopathology and have potentially identified a novel therapeutic target for treatment of CARD14-dependent psoriasis.
Date: 24 October 2022, 12:00 (Monday, 3rd week, Michaelmas 2022)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held in the Kennedy Institute Lecture Theatre is open to all Oxford University members. There is also the option to join via Zoom https://medsci.zoom.us/meeting/register/tJ0lcOGhqDkqEtWYB1MXjonIGlFoMrLYA_Eh
Speaker: Prof Steve Ley (UCL)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Ellen Mobbs (Kennedy Institute of Rheumatology), Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: ellen.mobbs@kennedy.ox.ac.uk
Host: Professor Tonia Vincent (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJ0lcOGhqDkqEtWYB1MXjonIGlFoMrLYA_Eh
Audience: Members of the University only
Editor: Ellen Mobbs