Effector and regulatory T cells balance in inflamed human livers
In person only
The liver is a complex immunological organ. It has both immunogenic and tolerogenic capacity. Tolerogenic potential of human liver with its protective firewalls is required to guard the body against the continuous influx of microbial product from the gut via the sinusoids and biliary tree. Immunotolerance and anergic state is maintained by a combined effort of both immune cells, parenchyma cells, epithelial and endothelial cells. Despite this, an unknown trigger can ignite the pathway towards breakdown in hepatic tolerance leading to autoimmune liver diseases. The human liver contains different subsets of effector lymphocytes that are kept in check by a subpopulation of T cells known as Regulatory T cells (Treg). The balance of effector and regulatory lymphocytes generally determines the outcome of hepatic inflammation: resolution, fulminant hepatitis, or chronic active hepatitis. Dissecting this pathology using the current technological advances is crucial to develop curative immune based therapies.
Date: 16 September 2024, 12:00 (Monday, 22nd week, Trinity 2024)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Lecture Theatre
Speaker: Prof Ye Htun Oo (University of Birmingham)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address: doris.chan@kennedy.ox.ac.uk
Host: Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Doris Chan