Climate change, poverty and health are inextricably linked. Safeguarding rural livelihoods from the destabilizing impacts of extreme weather events can promote the health and wellbeing of farmers, their families and communities, thereby ensuring a more resilient agricultural sector. This panel will consider whole-systems approaches to improve farmer health and wellbeing, from climate-sensitive health risks, their exposure pathways, and vulnerability factors, to the importance of enhancing the adaptive capacity and resilience of health and agricultural systems. We will explore these areas while considering the context-specific needs and priorities of rural communities, putting farmers’ health and wellbeing at the heart of this dialogue.